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张志国博士

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张志国:男,博士,副教授,硕士生导师。1977年生于黑龙江省延寿县,20129月加入九·三学社。吉林省优秀博士学位论文获得者。河南省高校科技创新人才。河南省高校青年骨干教师。截止201811月,在Angew. Chem. Int. Ed., Org. Lett., J. Org. Chem., Adv. Synth. Catal., Green Chem. Chem. Comm.等国际学术期刊已发表SCI 论文49 篇,长期从事并杂环类化合物的合成研究工作,尤其是天然产物母核结构的合成。 

 

 Email: zhangzg@htu.edu.cn
 

个人简历:
1998-2002
牡丹江师范大学化学系    理学学士
2002-2004
河北怀安第一中学     化学教师
2004-2010
东北师范大学化学学院     理学博士
2010-
现在 河南师范大学化学化工学院   化学教师

研究领域与兴趣:
有机合成化学;绿色合成化学;金属有机化学

主持的科研项目:

 1、国家自然科学基金 (21772032)N-芳基酰胺类惰性C(aryl)-N键直接活化/官能化反应研究

 2、国家自然科学基金 (21272057),单芳基双C-H 官能化策略在苯[d]杂环衍生物合成中的应用

 3、国家自然科学基金 (21002051),炔丙基全碳1,3-偶极子在构建呋喃并杂环衍生物中的应用

 4、国家博士后基金面上项目 (2012M521397),单芳基双C-H官能化新策略制备几种苯并杂环衍生物

 5、国家博士后特别资助项目 (2013T60701),呋喃并杂环合成新策略研究

 6、河南省自然科学基金 (1123004103121),天然产物杂环母核合成新方法

 7、河南省高等学校青年骨干教师资助计划 (2014GGJS-049)C(sp2)-H键活化/C(sp2)-N键形成反应在合成角型的杂环并喹啉酮类化合物中的应用

 8、河南省教育厅科技创新人才支持计划 (17HASTIT002),几种吡咯并杂环衍生物新合成策略研究

 9、河南省基础与前沿技术研究项目 (112300410312),天然产物杂环母核合成新方法

 10、联合基金河南省自然科学基金(162300410180),吡咯/呋喃/吡喃并喹啉类化合物的设计、合成与抗菌活性研究

 11、东北师范大学优秀博士论文基金,几种杂环并喹啉类生物碱的新合成策略研究

 

 

授权专利:

 1. 张志国,刘青锋,张贵生,田庆。高选择性地脱除2,6-二甲基-4-吡啶酮衍生物的α-单甲基的简单、有效的方法,申请日期:2012.11。授权日期:2014.08.27,中国,ZL201210469746.8  

2. 张志国,刘青锋,张贵生,田庆。2,6-二甲基-4-吡啶酮衍生物的2位和6位甲基的简单、有效的脱去方法,申请日期:2012.12。授权日期:2014.08.27,中国,ZL201210517552.0 

3. 张贵生,刘青锋,张志国,具有抗癌活性的3'-叠氮基表阿霉素的合成,申请日期:2011.01.14。授权日期:2014.06.25,中国,ZL201110023054.6 

研究论文:

 
 
 
 
1. Xiong, T.; Zhang, Q.;* Zhang, Z.; Liu, Q.* A Divergent Synthesis of γ-Iminolactones, Dihydroquinolin-2-ones, and γ-Lactames from β-Hydroxymethylcyclopropanylamides. The Journal of Organic Chemistry 2007, 72, 8005-8009.
    http://dx.doi.org/10.1021/jo701495s
       
 
Zhang, Q.;* Zhang, Z.; Yan, Z.; Liu, Q.;* Wang, T. A New Efficient Synthesis of Pyranoquinolines from 1-Acetyl N-Aryl Cyclopentanecarboxamides. Org Letters 2007, 9, 3651-3653.
   

 

 

 

 

 
 

 

 

 

 

 

 

 

http://dx.doi.org/10.1021/ol701536q


   

 

 

 

 

 
   

 

 

 

 

 

 

   

 

 

 

 

    3. Zhang, Z.; Zhang, Q.;* Sun, S.; Xiong, T.; Liu, Q.* Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline Derivatives. Angewandte Chemie International Edition 2007, 46, 1726-1729.      

 

 

 

 

 
 

 

 

 

 

http://dx.doi.org/10.1002/anie.200604276

   

 

 
     

 

   

 

   

 

 

 

 

 

 
 

 

 

   

 

 

 

 

 4. Zhang, Z.; Zhang, Q.;* Yan, Z.; Liu, Q.* One-Step Synthesis of the Tricyclic Core of Martinellic Acid from 2-(Cyanomethyl)-3-oxo-N-arylbutanamides. The Journal of Organic Chemistry 2007, 72, 9808-9810.

     

 

 

 

 

 
 

 

 

 

 

 

 

 

http://dx.doi.org/10.1021/jo701551f

     

 

 

 

 

     

 

 

 

 

 
   

 

 

5. Zhang, Z.; Zhang, Q.;* Ni, Z.; Liu, Q.* Ag-containing all-carbon 1,3-dipoles: generation and formal cycloaddition for furo[3,2-b]-β/γ-lactams. Chemical Communications 2010, 46, 1269-1271 (Highlight by SYNFACTS Synfacts, 2010, 5, 0524-0524).

 

 

 

   

 

 
http://dx.doi.org/10.1039/b917856b
       

 

   

 

   

 

 

 

 


 
 

 

 

   

 

 

 

 

6. Zhang, Z.; Xue, C.; Liu, X.; Zhang, Q.;* Liu, Q.* Synthesis of polysubstituted 3H-pyrimidin-4-ones from cyanoacetamides under Vilsmeier conditions. Tetrahedron 2011, 67, 7081-7084.

     
http://www.sciencedirect.com/science/article/pii/S004040201101009X             

 

 

 

 


     

 

 

 

 

 
7. Bi, J.; Zhang, Z.;* Liu, Q.; Zhang, G.* Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400. Green Chemistry 2012, 14, 1159-1162.  

 

 


 
   

 

 

 

 

http://dx.doi.org/10.1039/C2GC16661E  

 

 

         

 

   

 

 
     

 

 

 

 

8. Zhang, Z.;* Fang, S.; Liu, Q.; Zhang, G.* Microwave-Assisted Facile Synthesis of Furo[3,2-b]indole Derivatives via Silver(I)-Mediated [3+2] Cycloaddition. Advanced Synthesis & Catalysis 2012, 354, 927-932.      

 

 

 

 

 
 

 

 

 

 

         

 

 

 

 

     

 

 

 

 

 
 

 

 

 

 

         

 

 

 

 

     

 

 

 

 

 
 

 

 

 

 

         

 

 

 

 

         

 

 

 

           

 

 
   
           

 

 

 

 

   

 

           

 

 

 

 


           

 

 

 

 

   

 

 

 

 

 

 

 

 

http://dx.doi.org/10.1002/adsc.201100767 

     

 

 

 

 

 
 

 

 

 

       

 

 

 

 

   

 

   

 

 

         

 

 

 

 

 

 

 
               

 

 

 

 

         

 

 

 

9. Zhang, Z.;* Fang, S.; Liu, Q.; Zhang, G.* Approach to Polysubstituted 4-Pyridones from N-Aryl Acetoacetamides via a N to C 1,3-Acyl Migration Mediated by Sodium Persulfate. The Journal of Organic Chemistry 2012, 77, 7665-7670. 

     

 

 

 

 

           

 

 

 

 

   

 

           

 

 

 

 


           

 

 

 

 

   

 

 

 

 

 

 

 

 

http://dx.doi.org/10.1021/jo3010217

     

 

 

 

 

 
 

 

 

 

       

 

 

 

 

   

 

   

 

 

         

 

 

 

 

 

 

 
               

 

 

 

 

         

 

 

 

10. Zhang, Z.;* Bi, J.; Liu, Q.; Zhang, G.* The Synthesis of α,α-Difluoroacetamides via Electrophilic Fluorination in the Mixed-solvent of Water and PEG-400. Journal of Fluorine Chemistry 2013, 151, 45-49. 

     

 

 

 

 

 
 

 

 

 

 

         

 

 

 

 

     

 

 

 

 

 
 

 

 

 

 

         

 

 

 

 

     

 

 

 

 

 
 

 

 

 

 

         

 

 

 

 

         

 

 

 

           

 

 
   
http://dx.doi.org/10.1016/j.jfluchem.2013.03.016         

 

 

 

 


     

 

 

 

 

 
 

 

 

 

 

         

 

 

 

           

 

 


 

 

 

 
     

 

 

 

 

11. Zhang, Z.;* Wang, D.; Wang, B.; Liu, Q.; Liu, T.; Zhang, W.; Yuan, B.; Zhao, Z.; Han, D.; Zhang, G.* Tetrahedron 2013, 69, 9063.        

 

 

 

 

   

 

           

 

 

 

 


           

 

 

 

 

   

 

 

 

 

 

 

 

 

http://dx.doi.org/10.1016/j.tet.2013.08.027 

     

 

 

 

 

           

 

 

 

 

   

 

   

 

 

         

 

 

 

 

 

 

 
           

 

 

 

 

   

 

   

 

 

         

 

 

12. Li, Z.; Zhang, Z.;* Zhang, W.; Liu, Q.; Liu, T.; Zhang, G.* Copper-Mediated Sequential C–N and N–N Bond Formation: Facile Synthesis of Symmetrical 1,2,4-Triazoles. Synlett 2013, 24, 2735-2739.

 

 

 

 
https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0033-1338985    
   

 

  13.  Zhang, Z.;* Qian, J.; Tain, Q.; Liu, T.; Liu, Q.; Zhang, G.* Oxidative Nuclear Bromination of Substituted 4-Pyridones Using Pyridinium Bromochromate. Synthetic Communications 2014, 44, 674-81.    

 

 
     

 

http://dx.doi.org/10.1080/00397911.2013.834363

 

 

 

 

 

 

 

 

     

 

 

 

 

 
14. Zhang, L.; Zhang, Z.;* Liu, Q.; Liu, T.; Zhang, G.* Iron-Catalyzed Vinylogous Aldol Condensation of Biginelli Products and Its Application toward Pyrido[4,3-d]pyrimidinones. J. Org. Chem. 2014, 79, 2281-2288.    

 

 
  http://dx.doi.org/10.1021/jo402773r  

 

 

 


     

 

 

 

 

15. Zhang, Z.;Zhang, W.; Li, J.; Liu, Q.; Liu, T.; Zhang, G.* Synthesis of Multisubstituted Pyrroles from Doubly Activated Cyclopropanes Using an Iron-Mediated Oxidation Domino Reaction. J. Org. Chem., 201479, 11226–11233.   

 

 

   

 

     

 

 

 

 

     

 

http://pubs.acs.org/doi/abs/10.1021/jo5018487

 

 

 

  

     

 

 

 

 

 
   

  

   

 

 
     

 

 

 

 

  16. Zhang, Z.;* Tian, Q.; Qian, J.; Liu, Q.; Liu, T.; Shi, L.; Zhang, G.* Dimethyl Sulfoxide Participant Iron-Mediated Cascade Oxidation/alpha-Formylation Reaction of Substituted 2,3-Dihydropyrroles under Air and Protonic Acid Free Condition. J. Org. Chem., 201479, 8182–8188.   

 

 

   

 

     

 

 

 

 

 
   

 

 

 

 

http://dx.doi.org/10.1021/jo501385w 

     

 

 

 

 

 
   

 

 

 

 


   

17. Qian, J.; Zhang, Z.;* Liu, Q.; Liu, T.; Zhang, G.* Dimethyl Sulfoxide Participating in Copper(I) Iodide-Catalyzed Cascade Oxidation/Formylation Reactions: The Synthesis of alpha-Formylpyrroles from 2,3-Dihydro-1H-pyrroles. Adv. Synth. Catal., 2014356, 3119–3124. 

 

 

 

   

 

     

 

 

 

 

     

 

 

 

 

http://dx.doi.org/10.1002/adsc.201400332

   

 

 

 

 

 

    

     

 

 

 

 

 
 

18. Zhang, Z.;* Zhang, L.; Duan, X.; Yan, X.; Yan, Y.;Liu, Q.; Liu, T.; Zhang, G.* Iron-catalyzed four-member multicomponent reactionfor assembly of (E)-6-arylvinyl-3,4-dihydropyrimidin-2(1H)-ones. Tetrahedron 2015, 71, 7745-7751.

 

http://www.sciencedirect.com/science/article/pii/S0040402015010844      

19. Zhang, Z.;* Zhang, F.; Wang, H.; Wu, H.;Duan, X.; Liu, Q.; Liu, T.; Zhang, G.* Catalyst-Free Domino Reaction of1-Acryloyl-1-N-arylcarbamylcyclopropanes with Amines: One-Pot Approach to 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. Advanced Synthesis & Catalysis 2015,357, 2681-2686.  

 

 

 

http://dx.doi.org/10.1002/adsc.201500251    

 

 
     

 

 

 

 

   

 

  20. Zhang, Z.;* Li,J.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. Iron-Catalyzed IntramolecularC(sp(2))-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes towardPyrrolo[1,2-a]quinoxaline Derivatives. JOrg Chem 2015, 80, 6875-6884.  

 

 

   

 

     

 

 

 

 

 
   

 

 

 

 

http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b00915

   

 

 

 

 

   

 

     

 

 

 

 

21. Zhang, Z.;* Qian, J.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T.; Sun, K.; Shi, L. Copper(I) Catalyzed C(sp2)-N bond formation: Synthesis of Pyrrolo[3,2-c]quinolinone Derivatives. Org. Chem. Front. 2016, DOI: 10.1039/c5qo00417a.         

 

 

 

 

 
   

 

 

http://dx.doi.org/10.1039/C5QO00417A

   

 

 
     

 

 

 

 

   

 

 

 

   

 

     

 

 

 

 

22. Zhang, Z.;* Zheng, D.; Ma, N.; Bi, J., Brønsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolines. Chinese Journal of Organic Chemistry 2017, 37, 1824-1829.  http://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc201612032    

 

 

 

 

 

     

 

 

 

 

 
   

23.   Zhang, Z.;* Zhang, Y.; Huang, G.; Zhang, G.,* Organoiodine reagent-promoted intermolecular oxidative amination: synthesis of cyclopropyl spirooxindoles. Org. Chem. Front. 2017, 4, 1372-1375.

http://dx.doi.org/10.1039/C7QO00156H    

 

 

 

 

 

     

 

 

 

 

 
   

24.   Zhang, Z.;* Huang, Y.; Huang, G.; Zhang, G.;* Liu, Q., [Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C-N Bond Formation: Synthesis of 1H-Indazoles. Journal of Heterocyclic Chemistry 2017, 54, 2426. 

       

 

 

 

 

http://onlinelibrary.wiley.com/doi/10.1002/jhet.2839/full

   

 

 

 

 

 

     

 

 

 

 

 
   

25.   Zhang, Z.;* Gao, X.; Li, Z.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T., PIFA-Mediated oxidative cyclization of 1-aroyl-N-arylcyclopropane-1-carboxamides and their application in the synthesis of pyrrolo[3,2-c]quinolinones. Org. Chem. Front. 2017, 4, 404-408.

http://dx.doi.org/10.1039/C6QO00598E    

 

   

 

26. Liu, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Li, Z.; Bi, J.; Ma, N.; Liu, T.; Liu, Q., Oxidation of beta-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides. J Org Chem 2017, 82, 3901-3907.

http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b03062      

 

 

 

 

 

 

 

 

     

 

 

 

 

 
   

 

 

 

 

   

 

27. Zhang, Z.;* Li, J.; Huang, G.; Sun, K.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T., Copper(I)-Catalyzed Intramolecular N-N Coupling of Cyclopropyl O-Acyl Ketoximes: Synthesis of Spiro-fused Pyrazolin-5-ones. Chinese Journal of Chemistry 2016, 34, 1309-1320.       

 

 

 

http://dx.doi.org/10.1002/cjoc.201600479

   

 

 
     

 

 

 

 

 

 

 

 

     

 

 

 

 

 
   

 28. Yan, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Ma, N.; Liu, Q., Hypervalent Iodine(III)-Promoted Phenyl Transfer Reaction from Phenyl Hydrazides to Nitriles. J Org Chem 2017, 82, 7957-7963.

 

 

 

     

 

 

 

 

http://pubs.acs.org/doi/abs/10.1021/acs.joc.7b01215    

 

     

 

 

 

 

 
 

 

 

 

     

 

 

 

 

29. Zhang, Z.;* Huang, Y.; Huang, G.; Zhang, G.,* Ammonium Acetate-promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. ACS Omega  2017, 2, 6844-6851    

 

 
     

 

 

 

 

     

 

 

 

 

http://pubs.acs.org/doi/full/10.1021/acsomega.7b00626

 

 

 

 

     

 

 

30. Yan, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Ma, N.; Liu, Q., Hypervalent Iodine(III)-Promoted Phenyl Transfer Reaction from Phenyl Hydrazides to Nitriles. J Org Chem 2017, 82, 7957-7963.

 

 

 

http://pubs.acs.org/doi/abs/10.1021/acs.joc.7b01215 
   

 

 

 

 

 

 

     

 

 

 

 

     

 

 

 

 

31. Zhang, Z.; Zheng, D.; Wan, Y.; Zhang, G.; Bi, J.; Liu, Q.; Liu, T.; Shi, L., Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides. J. Org. Chem. 2018, 83, 1369-1376.
https://pubs.acs.org/doi/10.1021/acs.joc.7b02880

   

 

 

 

 

32. Hu, C.; Zhang, Z.; Gao, W.; Zhang, G.; Liu, T.; Liu, Q., PIFA-promoted intramolecular oxidative C(aryl)-H amidation reaction: Synthesis of quinolino[3,4-b]quinoxalin-6(5H)-ones. Tetrahedron 2018, 74, 665-671.
https://www.sciencedirect.com/science/article/pii/S004040201731267X

   

 

 

 

 

33. Zhang, Z.; Gao, X.; Yu, H.; Bi, J.; Zhang, G., Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its Applications. ACS Omega 2017, 2, 7746-7754.
http://dx.doi.org/10.1021/acsomega.7b01526

   

 

 

 

 

34. Wu, H.; Zhang, Z.; Ma, N.; Liu, Q.; Liu, T.; Zhang, G., Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions. J. Org. Chem. 2018, 83, 12880-12886.
https://doi.org/10.1021/acs.joc.8b01828

   

 

 

 

 

35.  Zhang, Z.; Gao, X.; Yu, H.; Zhang, G.; Liu, J., Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides. Advanced Synthesis & Catalysis 2018, 360, 3406-3411.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201800616
   

 

 

 

 

36.  Wu, H.; Zhang, Z.; Liu, Q.; Liu, T.; Ma, N.; Zhang, G., Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from o-Aminoacetophenones and Arylboronic Acids. Organic Letters 2018, 20, 2897-2901.
https://pubs.acs.org/doi/abs/10.1021/acs.orglett.8b00957
   

 

 

 

 

37.  Lu, N.; Zhang, Z.; Ma, N.; Wu, C.; Zhang, G.; Liu, Q.; Liu, T., Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-α-Iodomethyl Vinylsulfones. Organic Letters 2018, 20, 4318.
https://doi.org/10.1021/acs.orglett.8b01765
   

 

 

 

 

       

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